GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12618769 | 1 | rs11887056 | chr2:99243861 | UNC50 | chr2:99225042-99234975:+ | -0.2 | -4.12 | 4.1E-5 | Bipolar disorder |
| BRCA | cis | rs6748734 | 1 | rs11893118 | chr2:241828308 | C2orf54 | chr2:241825466-241835573:- | 0.3 | 8.75 | 8.31E-18 | Urinary metabolites |
| BRCA | cis | rs10205487 | 1 | rs11893500 | chr2:70154187 | ANXA4 | chr2:69969127-70053594:+ | -0.13 | -3.82 | 0.000138 | Carotid plaque burden (smoking interaction) |
| BRCA | cis | rs7589728 | 1 | rs11893832 | chr2:88507537 | THNSL2 | chr2:88469835-88486145:+ | -0.6 | -10.87 | 3.73E-26 | Plasma clusterin levels |
| BRCA | cis | rs11125529 | 1 | rs11896604 | chr2:54479199 | C2orf73 | chr2:54558071-54588714:+ | -0.15 | -3.81 | 0.000148 | Telomere length |
| BRCA | cis | rs6748734 | 1 | rs11898716 | chr2:241828311 | C2orf54 | chr2:241825466-241835573:- | 0.27 | 7.61 | 5.93E-14 | Urinary metabolites |
| BRCA | cis | rs9309473 | 1 | rs11899740 | chr2:73631212 | ALMS1P | chr2:73872046-73912692:+ | 0.23 | 5.65 | 2.08E-8 | Metabolite levels |
| BRCA | cis | rs10205487 | 1 | rs11902198 | chr2:70144596 | ANXA4 | chr2:69969127-70053594:+ | -0.14 | -3.95 | 8.45E-5 | Carotid plaque burden (smoking interaction) |
| BRCA | cis | rs10205487 | 1 | rs11902198 | chr2:70144596 | FAM136A | chr2:70523109-70529220:- | -0.09 | -3.43 | 0.000624 | Carotid plaque burden (smoking interaction) |
| BRCA | cis | rs4665058 | 1 | rs11903934 | chr2:160122538 | WDSUB1 | chr2:160092305-160143236:- | 0.33 | 3.96 | 7.86E-5 | Sudden cardiac arrest |
| BRCA | cis | rs13393800 | 1 | rs1190447 | chr2:233420052 | EIF4E2 | chr2:233415357-233448349:+ | 0.19 | 4.38 | 1.29E-5 | Height |
| BRCA | cis | rs13393800 | 1 | rs1190447 | chr2:233420052 | TIGD1 | chr2:233412779-233415226:- | 0.13 | 3.44 | 0.000595 | Height |
| BRCA | cis | rs13393800 | 1 | rs1190450 | chr2:233418302 | EIF4E2 | chr2:233415357-233448349:+ | 0.18 | 4.14 | 3.82E-5 | Height |
| BRCA | cis | rs13393800 | 1 | rs1190450 | chr2:233418302 | TIGD1 | chr2:233412779-233415226:- | 0.14 | 3.57 | 0.000377 | Height |
| BRCA | cis | rs2273905 | 1 | rs1190553 | chr14:102915331 | ANKRD9 | chr14:102973198-102976128:- | -0.13 | -3.93 | 9.01E-5 | QT interval |